1,2,3,4-Tetrahydroisoquinoline → HCID 22117335, compound

HRID 1275558Notes

Reaction equation

HRID 1275558 reaction equation
Cl.Cl.Cl[CH2:4][CH2:5][CH2:6][S:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[C:9]=1[CH3:22].[CH2:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][NH:24]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:22][C:9]1[C:10]([CH2:14][S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[N:11][CH:12]=[CH:13][C:8]=1[S:7][CH2:6][CH2:5][CH2:4][N:24]1[CH2:25][CH2:26][C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23]1

Participants

4

Reactant 3

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 11430Potassium CarbonateHCID 22117318HCID 22117318, compound

Product 1

HCID 22117335HCID 22117335, compoundYield 46%

Procedure

According to the procedure described in Example 7, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(2-pyridinylthio)methyl]pyridine dihydrochloride with 1,2,3,4-tetrahydroisoquinoline and potassium carbonate gives the title compound; m.p. hygroscopic; dec. from 58° C.; yield 46% of theory.

Sources & evidence

ORD record
ord-558bb083262d4a39b8024e8be41aa744
Source dataset
uspto-grants-2000_12
Patent number
US06162809

Reaction notes

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