Potassium Carbonate → HCID 22117339, compound

HRID 1275565Notes

Reaction equation

HRID 1275565 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[C:7]=1[CH3:20].[Cl:21][C:22]1[S:26][C:25]([CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1.C(=O)([O-])[O-].[K+].[K+]>>[ClH:1].[ClH:21].[ClH:1].[Cl:21][C:22]1[S:26][C:25]([CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][S:5][C:6]3[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[C:7]=3[CH3:20])[CH2:30][CH2:29]2)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 24550121-[(5-Chloro-2-thienyl)methyl]piperazineHCID 221173024-(3-Chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine

Product 1

HCID 22117339HCID 22117339, compoundYield 79%

Procedure

According to the procedure indicated in Example 7, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with [1-(5-chlorothiophen-2-yl)methyl]piperazine and potassium carbonate gives, after crystallization from isopropanol/acetone/conc. hydrochloric acid, the title compound; m.p. 160-162° C., dec.; yield 79% of theory.

Workup

  1. customgives
  2. customafter crystallization from isopropanol/acetone/conc

Sources & evidence

ORD record
ord-4343c5501e6b409b91bb018637b73ae7
Source dataset
uspto-grants-2000_12
Patent number
US06162809

Reaction notes

Loading…