Hydrochloric Acid → HCID 15480989, compound

HRID 1275677Notes

Reaction equation

HRID 1275677 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[CH:14]=2)=[CH:7][CH:6]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+].O.Cl>CO>[F:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[F:19])[CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 15480988HCID 15480988, compound

Product 1

HCID 15480989HCID 15480989, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-(3,4-difluorobenzyloxy)phenyl acetate (6.77 g, 24.4 mmol) in methanol (100 ml) was added potassium carbonate (3.36 g, 24.3 mmol), followed by reflux for 3 hours. After allowing to stand overnight, the reaction solution was poured into water, made acidic with hydrochloric acid and extracted with chloroform. The solvent was evaporated under reduced pressure to give the title compound (5.68 g), which was used for the following reaction without purification.

Workup

  1. temperatureby reflux for 3 hours
  2. extractionextracted with chloroform
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a75cac89e6bb4912b8cae316a194b16f
Source dataset
uspto-grants-2000_12
Patent number
US06162832

Reaction notes

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