Hydrochloric Acid → HCID 12940626, compound

HRID 1275678Notes

Reaction equation

HRID 1275678 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])=[CH:7][CH:6]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+].O.Cl>CO>[N+:18]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[O:11][C:8]1[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=1)([O-:20])=[O:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 22117709HCID 22117709, compound

Product 1

HCID 12940626HCID 12940626, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-(2-nitrophenoxy)phenyl acetate (6.32 g, 23.2 mmol) in methanol (100 ml) was added potassium carbonate (6.39 g, 46.3 mmol), followed by reflux for 3 hours. The reaction solution was poured into water, made acidic with hydrochloric acid and extracted with chloroform. The organic layer was washed with water and a saturated aqueous sodium chloride solution and dried. The solvent was evaporated under reduced pressure to give the title compound (5.35 g).

Workup

  1. temperatureby reflux for 3 hours
  2. extractionextracted with chloroform
  3. washThe organic layer was washed with water
  4. dry with materiala saturated aqueous sodium chloride solution and dried
  5. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5149ff16f84b4bad92cea422fd8f5eda
Source dataset
uspto-grants-2000_12
Patent number
US06162832

Reaction notes

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