Ammonium Chloride → HCID 22117681, compound

HRID 1275684Notes

Reaction equation

HRID 1275684 reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)([O-])=O.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:1][C:4]1[CH:17]=[CH:16][CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 12940626HCID 12940626, compound

Product 1

HCID 22117681HCID 22117681, compoundYield 98.2%

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 4-(2-nitrophenoxy)phenol (1.00 g, 4.3 mmol) in ethanol (50 ml) were added an iron powder (1.21 g, 0.022 g-atom) and a solution of ammonium chloride (0.14 g, 2.6 mmol) in water (10 ml), followed by reflux for 2 hours. The insoluble matter was filtered, and the solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate, and after drying, the solvent was evaporated under reduced pressure to give 4-(2-aminophenoxy)phenol (0.85 g).

Workup

  1. temperatureby reflux for 2 hours
  2. filtrationThe insoluble matter was filtered
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. customafter drying
  6. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a7be411cd97347c0ba42e31b868c205f
Source dataset
uspto-grants-2000_12
Patent number
US06162832

Reaction notes

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