反应详情

2.97 ml (5.94 mmol) of a 2M solution of methylamine in THF were initially charged in 20 ml of THF, and a solution of 0.8 g (2.4 mmol) of 1-benzyl-3-(5-chlorocarbonyl-2-furyl)indazole in 10 ml of THF was added dropwise at RT. After 1 h, the mixture was poured into ice-water and the oil that separated off was extracted with ethyl acetate. The organic phase was washed with 1N hydrochloric acid, dried and concentrated using a rotary evaporator. The crude product was recrystallized from isopropanol. This gave 0.44 g (55%) of the title compound. m.p.: 182-183° C.

1. customthe oil that separated off
2. extractionwas extracted with ethyl acetate
3. washThe organic phase was washed with 1N hydrochloric acid
4. customdried
5. concentrationconcentrated
6. customa rotary evaporator
7. customThe crude product was recrystallized from isopropanol