反应详情

To a solution of potassium tert-butoxide (67.5 g) in tetrahydrofuran (500 ml) was added 5-bromo-2,4-dichloropyrimidine (55 g) (J. Am. Chem. Soc. 1934, 56, 134) in tetrahydrofuran (100 ml) dropwise. After 1.5 hours, water (100 ml) was added carefully and the mixture extracted with ethyl acetate. The combined organic solution was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 5% triethylamine in isohexane to give the product as a solid. Yield 52.4 g

1. extractionthe mixture extracted with ethyl acetate
2. washThe combined organic solution was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with 5% triethylamine in isohexane