Triphenylphosphine → HCID 22117256, compound

HRID 1275896Notes

Reaction equation

HRID 1275896 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12]Br)[CH:3]=1.[C:14]1([P:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(#N)C>[Br-:1].[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][P+:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoate

Product 1

HCID 22117256HCID 22117256, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The product of step (i) (26.45 g) and triphenylphosphine (11.7 g) in acetonitrile (100 ml) was heated under reflux for 1.5 hours. The solvent was evaporated and the residue triturated with diethyl ether. The precipitate was collected. Yield 22.8 g. Used directly in the next step.

Workup

  1. temperatureunder reflux for 1.5 hours
  2. customThe solvent was evaporated
  3. customthe residue triturated with diethyl ether
  4. customThe precipitate was collected

Sources & evidence

ORD record
ord-f26ad50101fb42b3828eaf1257be7d49
Source dataset
uspto-grants-2000_12
Patent number
US06162808

Reaction notes

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