Tetrahydrofuran → HCID 22114874, compound

HRID 1276045Notes

Reaction equation

HRID 1276045 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2S(C)(=O)=O)=[CH:4][CH:3]=1.O1CCCC1.O.[NH2:29][NH2:30]>[Cl-].[Na+].O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2[NH:29][NH2:30])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 24654Hydrazine hydrate (1:1)HCID 22114881HCID 22114881, compound

Product 1

HCID 22114874HCID 22114874, compound

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent

Procedure

A mixture of 3-(4-chlorophenyl)-3,4-dihydro-2-methanesulfonyl-6-trifluoromethylpyrimidin-4-one (2.0 g) and tetrahydrofuran (20 ml) was added with hydrazine monohydrate (NH2NH2. H2O) (0.5 g). After stirring for 30 minuets at room temperature, the mixture was added with saturated brine (30 ml) and then extracted with ethyl acetate. The extract layer was washed with water and then dried on anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give the compound of interest (1.5 g) as a milk white solid.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract layer was washed with water
  3. dry with materialdried on anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off under reduced pressure
  5. customto give the compound of interest (1.5 g) as a milk white solid

Sources & evidence

ORD record
ord-1e6e16296f81487c825ecc998ffa8ec8
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

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