反应详情

An ethanolic solution of t-butyl bromoacetate (39 g, 0.2 mol) was added dropwise to a stirred chilled ethanolic solution containing cyclobutyl amine (28.4 g, 0.4 mol) and triethylamine (25.3 g, 0.25 mol). After stirring overnight at room temperature, the reaction mixture was concentrated and the residue redissolved in methylene chloride (300 ml). This solution was washed with water (3×500 ml), dried over MgSO4, filtered, and evaporated to dryness, yielding 24.9 g (67%) of the desired product as a light brown oil.

1. temperaturechilled ethanolic solution
2. concentrationthe reaction mixture was concentrated
3. dissolutionthe residue redissolved in methylene chloride (300 ml)
4. washThis solution was washed with water (3×500 ml)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated to dryness