Oxalyl chloride → HCID 22116158, compound

HRID 1276379Notes

Reaction equation

HRID 1276379 reaction equation
C(Cl)(=O)C([Cl:4])=O.[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:16]([CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:32][CH2:33][CH2:34][O:35][CH3:36])[C:29](O)=[O:30])=[CH:23][CH:22]=1)[CH3:17]>ClCCl>[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:16]([CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:32][CH2:33][CH2:34][O:35][CH3:36])[C:29]([Cl:4])=[O:30])=[CH:23][CH:22]=1)[CH3:17]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 22116154HCID 22116154, compound

Product 1

HCID 22116158HCID 22116158, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (92 mg) was added to (±)-3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]phenyl]-2-(2-methoxyethoxy)propanoic acid (100 mg) in dichloromethane (2 mL). The mixture was stirred at room temperature for 16 hours and evaporated to dryness to give the title compound as a gum which was used without further purification.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-798b0b314db847ccafdc8dcc0d249b08
Source dataset
uspto-grants-2000_12
Patent number
US06166049

Reaction notes

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