Ammonium Hydroxide → Benzene-1,3-disulfonic Acid Amide Tert-butyl Amide

HRID 1276520Notes

Reaction equation

HRID 1276520 reaction equation
[OH-].[NH4+:2].[C:3]([NH:7][S:8]([C:11]1[CH:12]=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1)(=[O:10])=[O:9])([CH3:6])([CH3:5])[CH3:4]>C(OCC)(=O)C>[C:3]([NH:7][S:8]([C:11]1[CH:12]=[C:13]([S:17]([NH2:2])(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1)(=[O:10])=[O:9])([CH3:6])([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 167932863-Tert-butylsulfamoyl-benzenesulfonyl chloride

Product 1

HCID 31065078Benzene-1,3-disulfonic Acid Amide Tert-butyl Amide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

20 ml of concentrated ammonium hydroxide was added to a solution of 1 gram (3.2 mmole) 3-tert-butylsulfamoyl-benzenesulfonyl chloride in ethyl acetate. It was stirred vigorously for 8 hours. The ethyl acetate layer was separated dried over magnesium sulfate in vacuo to give 320 mg of the titled compound as a white solid. m.p. 151-154° C.

Workup

  1. customThe ethyl acetate layer was separated
  2. dry with materialdried over magnesium sulfate in vacuo

Sources & evidence

ORD record
ord-22afa1b8447448f79ef56697f7e04141
Source dataset
uspto-grants-2000_12
Patent number
US06166064

Reaction notes

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