Cyclobutylamine → Benzene-1,3-disulfonic acid tert-butyl-amide cyclobutylamide

HRID 1276522Notes

Reaction equation

HRID 1276522 reaction equation
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[C:6]([NH:10][S:11]([C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1)(=[O:13])=[O:12])([CH3:9])([CH3:8])[CH3:7]>>[CH:1]1([NH:5][S:20]([C:16]2[CH:15]=[C:14]([S:11]([NH:10][C:6]([CH3:9])([CH3:8])[CH3:7])(=[O:13])=[O:12])[CH:19]=[CH:18][CH:17]=2)(=[O:22])=[O:21])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 167932863-Tert-butylsulfamoyl-benzenesulfonyl chloride

Product 1

HCID 70000986Benzene-1,3-disulfonic acid tert-butyl-amide cyclobutylamide

Procedure

Using a procedure similar to that described in Preparation E, 4 ml of cyclobutylamine was added to 1 gram (3.9 mmole) of 3-tert-butylsulfamoyl-benzenesulfonyl chloride to give 813 mg of the titled compound.

Sources & evidence

ORD record
ord-3ee33d8b29be4ce8a227afed9bccae8b
Source dataset
uspto-grants-2000_12
Patent number
US06166064

Reaction notes

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