Acetyl chloride → HCID 70003051, compound

HRID 1276529Notes

Reaction equation

HRID 1276529 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH2:10][CH2:9]2.C(N(CC)CC)C>C(Cl)Cl.O>[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]([C:1](=[O:3])[CH3:2])[CH2:9]2

Participants

6

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 27744635-Fluoroindoline

Product 1

HCID 70003051HCID 70003051, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (3 ml) was added dropwise to a solution of 7 grams of crude 5-fluoro-2,3-dihydro--1H-indole and 3 ml of triethylamine in 100 ml of CH2Cl2 at 0° C. After two hours, the reaction was diluted with water. The methylene chloride layer was separated, dried and evaporated to afford 7.3 grams of crude product which was purified on silica gel eluting with hexane/ethyl acetate to give 3.3 grams of the titled compound.

Workup

  1. customThe methylene chloride layer was separated
  2. customdried
  3. customevaporated
  4. customto afford 7.3 grams of crude product which
  5. customwas purified on silica gel eluting with hexane/ethyl acetate

Sources & evidence

ORD record
ord-872d846eeee442b8b15016683edb57e6
Source dataset
uspto-grants-2000_12
Patent number
US06166064

Reaction notes

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