Methyl 5-iodo-2-isothiocyanatobenzoate → Methyl 5-iodo-2-[(propoxythioxomethyl)amino]benzoate
Reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]([N:12]=[C:13]=[S:14])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]>C(O)CC>[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13]([O:8][CH2:7][CH2:6][CH3:5])=[S:14])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The process of claim 10 wherein (a) methyl 2-amino-5-iodobenzoate is treated to form methyl 5-iodo-2-isothiocyanatobenzoate; (b) the methyl 5-iodo-2-isothiocyanatobenzoate is treated with n-propanol to form methyl 5-iodo-2((propoxy-thioxomethyl)-amino)benzoate, and (c) the methyl 5-iodo-2-((propoxythioxomethyl)-amino)benzoate is treated with propylamine.
Sources & evidence
- ORD record
- ord-588cb0181dad480c8097a4affb913b70
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06166208
Reaction notes
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