HCID 53714761, compound → 122331-77-5

HRID 1276675Notes

Reaction equation

HRID 1276675 reaction equation
[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH3:47])=[C:10]([CH:46]=2)[C@@H:11]([C:34]2[C:43]([CH3:44])=[CH:42][C:37]([C:38]([O:40]C)=[O:39])=[CH:36][C:35]=2[CH3:45])[O:12]C(=O)[C@@H](NS(C2C=CC(C)=CC=2)(=O)=O)CC2C=CC=CC=2)[CH:5]=[CH:4][N:3]=[CH:2]1>CN(C)C=O>[OH:12][C@H:11]([C:34]1[C:35]([CH3:45])=[CH:36][C:37]([C:38]([OH:40])=[O:39])=[CH:42][C:43]=1[CH3:44])[C:10]1[CH:46]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:7]=[CH:8][C:9]=1[CH3:47]

Participants

3

Reactant 1

HCID 53714761HCID 53714761, compound

Product 1

HCID 11056808122331-77-5

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Example 5 was treated in the same manner as in Example 2 to give 13.8 g of (S)-4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid, melting point 286-288° C. (decomposition), optical rotation [α]D21 -261.5° (c=1.0, dimethylformamide).

Sources & evidence

ORD record
ord-9bed6ae0c4e3406abdefebfb8d05b9ea
Source dataset
uspto-grants-2000_12
Patent number
US06166221

Reaction notes

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