Hydrochloric Acid → HCID 67519706, compound

HRID 12768Notes

Reaction equation

HRID 12768 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[C:5]([CH3:34])[O:4][N:3]=1.[ClH:35]>O1CCOCC1>[ClH:35].[CH3:1][C:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[C:5]([CH3:34])[O:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 247592365-(3,5-dimethyl-4-isoxazolyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 67519706HCID 67519706, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5-(3,5-dimethyl-4-isoxazolyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (500 μl) to give the title compound as a white solid.

Sources & evidence

ORD record
ord-efe0c6d0bf7749698b9246fbf7b93084
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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