Hydrochloric Acid → HCID 68692768, compound

HRID 12769Notes

Reaction equation

HRID 12769 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[CH:13]=2)[CH:5]=[CH:4][N:3]=1.[ClH:35].O1CCOCC1>>[ClH:35].[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:28]=5)([CH2:20]4)[CH2:18]3)[CH:13]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 24759237HCID 24759237, compound

Product 1

HCID 68692768HCID 68692768, compound

Procedure

5-(2-methyl-4-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (1 eq) to give the title compound as a white solid. (32 mg)

Sources & evidence

ORD record
ord-bfd1cb1a2e094032ba781c3474bebb44
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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