Hydrochloric Acid → HCID 54369018, compound

HRID 1277336Notes

Reaction equation

HRID 1277336 reaction equation
[NH2:1][CH:2]([C:4]1([CH:10]([C:16]([F:19])([F:18])[F:17])[CH:11]([CH3:15])[C:12]([OH:14])=[O:13])SCCCS1)[CH3:3].Cl.C(#N)C.CI.[OH2:26]>>[NH2:1][C@H:2]([C:4]([CH:10]([C:16]([F:19])([F:18])[F:17])[CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[O:26])[CH3:3]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 6328Methyl iodideHCID 6342AcetonitrileHCID 12895629HCID 12895629, compound

Product 1

HCID 54369018HCID 54369018, compound

Conditions

Temperature
25 °C

Procedure

The above named compound is prepared by treating 317 mg (1 mMole) of 3-[2-(1-aminoethyl)1,3-dithian-2-yl]-4,4,4-trifluoro-2-methylbutyric acid with 1.0 ml of 1 N HCl and 10 ml of acetonitrile followed by treatment with 2 ml of methyl iodide. The mixture is stirred at 25° C. for 48hours then diluted with water. The mixture is then thoroughly washed with ether and the aqueous phase is concentrated to afford 3-alanyl-4,4,4-trifluoro-2-methylbutyric acid.

Workup

  1. customis prepared
  2. washThe mixture is then thoroughly washed with ether
  3. concentrationthe aqueous phase is concentrated

Sources & evidence

ORD record
ord-2660ce901ba84f22a4b3e0fa38c49e45
Source dataset
uspto-grants-1981_07
Patent number
US04277395

Reaction notes

Loading…