Hydrochloric Acid → HCID 86737836, compound

HRID 1277340Notes

Reaction equation

HRID 1277340 reaction equation
C[O:2][C:3](=[O:30])[CH:4]([CH3:29])[CH:5]([C:10]1([CH:16]([N:18]2C(=O)C3=CC=CC=C3C2=O)[CH3:17])[S:15][CH2:14][CH2:13][CH2:12][S:11]1)[C:6]([F:9])([F:8])[F:7].O.NN.[ClH:34]>C(O)C>[ClH:34].[NH2:18][CH:16]([C:10]1([CH:5]([C:6]([F:8])([F:9])[F:7])[CH:4]([CH3:29])[C:3]([OH:30])=[O:2])[S:11][CH2:12][CH2:13][CH2:14][S:15]1)[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 86737835HCID 86737835, compound

Product 1

HCID 86737836HCID 86737836, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 1.1 g of the product of Example 5 in 20 ml of ethanol is treated with hydrazine hydrate (2 ml) for 2 hours at reflux. The ethanol is evaporated and the residue treated with 1 N NaOH then extracted with ether. The ether solution is dried and concentrated leaving a residue thatis taken up in 20 ml of ethanol and 10 ml of 6 N HCl and heated at reflux for 1 hour. The solvents are evaporated to give the title compound.

Workup

  1. temperatureat reflux
  2. customThe ethanol is evaporated
  3. additionthe residue treated with 1 N NaOH
  4. extractionthen extracted with ether
  5. dry with materialThe ether solution is dried
  6. concentrationconcentrated
  7. customleaving a residue thatis
  8. temperatureat reflux for 1 hour
  9. customThe solvents are evaporated

Sources & evidence

ORD record
ord-3cf42a1a2b9d420fb3d85bdfd2d39b80
Source dataset
uspto-grants-1981_07
Patent number
US04277395

Reaction notes

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