Pyrrolidine → HCID 23453673, compound

HRID 1277361Notes

Reaction equation

HRID 1277361 reaction equation
[IH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[C:16]2([CH2:20][CH2:19][C:18](SC)=[N:17]2)[CH:14]2[CH2:15][CH:11]1[CH2:12][CH2:13]2.[NH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>C(O)C>[IH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[C:16]2([CH2:20][CH2:19][C:18]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[N:17]2)[CH:14]2[CH2:15][CH:11]1[CH2:12][CH2:13]2

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 23453746HCID 23453746, compound

Product 1

HCID 23453673HCID 23453673, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12 mmoles of 3-(2-methoxyphenyl)-5'-methylthio-spiro[bicyclo[2.2.1]-heptane-2,2'-5-pyrroline]hydriodide and 2 g of pyrrolidine in 50 ml of ethanol are refluxed. The solvent is stripped off and the residue obtained is recrystallized from isopropanol. Colorless crystals of melting point 228° C.

Workup

  1. customthe residue obtained
  2. customis recrystallized from isopropanol

Sources & evidence

ORD record
ord-840bcb1e2b2145c994a7fc9b8ffdc056
Source dataset
uspto-grants-1981_07
Patent number
US04277470

Reaction notes

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