Acetic Acid → HCID 12802474, compound

HRID 1277391Notes

Reaction equation

HRID 1277391 reaction equation
[NH:1]([C:36]([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=[O:37])[C@H:2]([C:11]([NH:13][C@@H:14]([C:16]([NH:18][CH2:19][C:20]([N:22]([CH3:35])[C@H:23]([C:31]([NH:33][NH2:34])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21])=[O:17])[CH3:15])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[C:46](O)(=[O:48])[CH3:47]>CN(C=O)C>[NH:1]([C:36]([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=[O:37])[C@H:2]([C:11]([NH:13][C@@H:14]([C:16]([NH:18][CH2:19][C:20]([N:22]([CH3:35])[C@H:23]([C:31]([NH:33][NH:34][C:46]([CH3:47])=[O:48])=[O:32])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:21])=[O:17])[CH3:15])=[O:12])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 12802456HCID 12802456, compound

Product 1

HCID 12802474HCID 12802474, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same manner as Example 14-(I), 426 mg of Z-Tyr-(D)-Ala-Gly-MePhe-NH-NH2 and 0.06 ml of acetic acid are used toproduce 405 mg of the indicated compound (85%). m.p.142°-143°C.; Rf1 =0.33; [α]D27 -31.8°(c=0.4, DMF)

Sources & evidence

ORD record
ord-f641dd65824d451692e0d7321f431baa
Source dataset
uspto-grants-1981_07
Patent number
US04277394

Reaction notes

Loading…