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HRID1277394

反应详情

EQUATION

反应方程式

HRID 1277394 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CNC(=O)[C@@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
HCID12919643

未命名化合物

PRODUCTS

生成物

1
结构：CSCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)O
HCID12919645

N-(tert-Butoxycarbonyl)-L-tyrosyl-D-methionylglycine

C21H31N3O7S

收率 87.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In 30 ml of MeOH is dissolved 2.8 g of BOC-Tyr-(D)-Met-Gly-OEt. After cooling, 12 ml of N-aqueous sodium hydroxide solution is added, and the mixture is stirred at room temperature for 1 hour. After cooling, 60 ml of0.2 N-aqueous hydrochloric acid solution is added, and the precipitated crystals are collected by filtration, followed by washing with cold water.Thus obtained is 2.3 g of the desired product, m.p. 184°-186°C., Rf1 =0.24, [α]D21 +13.3° (c=0.46, DMF)

WORKUP

后处理

  1. temperatureAfter cooling
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals are collected by filtration
  4. washby washing with cold water
  5. customThus obtained