Oxalyl chloride → 2-Trifluoromethylhexanoyl chloride

HRID 127785Notes

Reaction equation

HRID 127785 reaction equation
[F:1][C:2]([F:12])([F:11])[CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4](O)=[O:5].C(Cl)(=O)C([Cl:16])=O>>[F:1][C:2]([F:12])([F:11])[CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4]([Cl:16])=[O:5]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 157451932-Trifluoromethylhexanoic acid

Product 1

HCID 202859472-Trifluoromethylhexanoyl chlorideYield 90%

Procedure

2-Trifluoromethylhexanoic acid (2.3 g.) was added dropwise to 10 g. oxalyl chloride (10 g.) and the mixture heated to reflux for 2 hours. Distillation of the reaction mixture after this time yielded 2-trifluoromethylhexanoyl chloride (2.27 g.; 90%), b.p. 67°-70°/43 mmHg.

Workup

  1. temperatureto reflux for 2 hours
  2. distillationDistillation of the reaction mixture after this time

Sources & evidence

ORD record
ord-30039d14f8c14445b8190fb9e7e5b2b3
Source dataset
uspto-grants-1981_03
Patent number
US04256911

Reaction notes

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