Benzene → N-cyclohexyl-2-iodobenzamide

HRID 1277908Notes

Reaction equation

HRID 1277908 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[I:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](Cl)=[O:12].C1C=CC=CC=1>O1CCCC1>[CH:1]1([NH:7][C:11](=[O:12])[C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[I:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 241BenzeneHCID 7965CyclohexylamineHCID 691122-Iodobenzoyl chloride

Product 1

HCID 774524N-cyclohexyl-2-iodobenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In accordance with the procedure of Example 3, 12.1 g of cyclohexylamine was reacted with 8.0 g of o-iodobenzoyl chloride in 20 ml of tetrahydrofuran. There was obtained by recrystallization from benzene 5.7 g of fine white crystals of N-cyclohexyl-o-iodobenzamide, m.p. 148°-149°, Rf 0.74.

Sources & evidence

ORD record
ord-30d02f69c90c46a4bc2ac1f1ba84d41b
Source dataset
uspto-grants-1981_07
Patent number
US04279887

Reaction notes

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