Dimethylamine → 4-iodo-N,N-dimethylbenzamide

HRID 1277914Notes

Reaction equation

HRID 1277914 reaction equation
[CH3:1][NH:2][CH3:3].[I:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1>>[CH3:1][N:2]([CH3:3])[C:9](=[O:10])[C:8]1[CH:12]=[CH:13][C:5]([I:4])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 743734-Iodobenzoyl chloride

Product 1

HCID 8799334-iodo-N,N-dimethylbenzamide

Procedure

A total of 20 ml of a 40% aqueous solution of dimethylamine was reacted with a solution of 5.4 g p-iodobenzoyl chloride as described in Example 3 and recrystallized from a benzene/hexane mixture to yield 4.9 g N, N-dimethyl-p-iodobenzamide as white crystals, m.p. 113°-115°, Rf 0.69.

Workup

  1. customrecrystallized from a benzene/hexane mixture

Sources & evidence

ORD record
ord-6c9de6e93f0a4e79a4cead7084b2cf2d
Source dataset
uspto-grants-1981_07
Patent number
US04279887

Reaction notes

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