Methane → HCID 12763981, compound

HRID 1277971Notes

Reaction equation

HRID 1277971 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]1[CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=[C:8]1[CH:7]=[CH:6]2.[OH-].[Na+].C>O.C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]1[CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=[C:8]1[CH:7]=[CH:6]2

Participants

6

Reactant 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 12763982HCID 12763982, compound

Product 1

HCID 12763981HCID 12763981, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

840 mg of ethyl 7-methoxyimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in a mixture of 100 ml of water and 150 ml of ethanol and 3.5 ml of N sodium hydroxide solution were added. The mixture was heated on a steam bath for 30 minutes and the resulting solution was decolorized with charcoal, filtered and acidified with 3.7 ml of N hydrochloric acid. The mixture was cooled in ice to obtain colorless crystals of 7-methoxyimidazo-[1,2-a]-quinoline-2-carboxylic acid melting at 265°-266° C.

Workup

  1. additionwere added
  2. temperatureThe mixture was heated on a steam bath for 30 minutes
  3. filtrationfiltered
  4. temperatureThe mixture was cooled in ice

Sources & evidence

ORD record
ord-1f5fd342702241529b6171170e28c32c
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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