1-Bromohexane → HCID 23452539, compound

HRID 1278064Notes

Reaction equation

HRID 1278064 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>CC(CC)=O>[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]2[CH2:11][CH2:10][CH2:9][N:8]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 81011-BromohexaneHCID 11430Potassium CarbonateHCID 5138807HCID 5138807, compound

Product 1

HCID 23452539HCID 23452539, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Boil 5 g of 2-(4-chlorobenzyl)pyrrolidine, 3.53 g of anhydrous potassium carbonate, 4.6 g of 1-bromohexane and 50 ml of ethyl methyl ketone under reflux for 18 hours. Work up according to the procedure o Example 67 to obtain 5.82 g (81% of theory) of the title compound as a colorless liquid of b.p. 110° to 112° at 0.005 mm of Hg.

Sources & evidence

ORD record
ord-1193b2d7d4c64e64b9fd2b35f3c590c3
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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