反应详情

Add (dropwise at 80°, with stirring) a solution of 3.5 g of sodium in 80 ml of ethanol to a mixture of 16.1 g of 3,4-methylenedioxybenzylcyanide and 36 g of 2-dimethylamino-1-methyl-1-pyrrolinium-methylsulfate. Continue boiling the resulting reaction mixture for a further 2 hours. Then distil off the solvent under a vacuum and take up the residue with water/diethyl ether. Collect the ethereal layer. Dry it over sodium sulfate and concentrate it to obtain 18 g (67% of theory) of the title compound as oily liquid.

1. additionAdd (dropwise at 80°
2. customthe resulting reaction mixture for a further 2 hours
3. customThen distil off the solvent under a vacuum
4. customCollect the ethereal layer
5. dry with materialDry it over sodium sulfate
6. concentrationconcentrate it