Hydrochloric Acid → HCID 10064729, compound

HRID 1278161Notes

Reaction equation

HRID 1278161 reaction equation
[CH2:1]([S:8]([C:11]1[N:15]=[CH:14][NH:13][N:12]=1)(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([N:18]([CH2:22][CH3:23])[C:19](Cl)=[O:20])[CH3:17].Cl>N1C=CC=CC=1>[CH2:1]([S:8]([C:11]1[N:15]=[CH:14][N:13]([C:19](=[O:20])[N:18]([CH2:22][CH3:23])[CH2:16][CH3:17])[N:12]=1)(=[O:10])=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6916Diethylcarbamoyl chlorideHCID 178527388HCID 178527388, compound

Product 1

HCID 10064729HCID 10064729, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 3-benzylsulfonyl-1,2,4-triazole, 4.8 g (0.022 m) in 25 ml dry pyridine, 3.3 g (0.024 m) diethylcarbamoyl chloride is added dropwise. Let it stir overnight and pour into ~100 ml cold dilute hydrochloric acid. The product is extracted with ethyl acetate. Dry the organic layer and evaporate to give the desired product. Recrystallize from toluene-hexane to give white crystals, 5.8 g (81%) m.p. 87°-88° C.

Workup

  1. extractionThe product is extracted with ethyl acetate
  2. customDry the organic layer
  3. customevaporate

Sources & evidence

ORD record
ord-8b7a155be1b44f3b97d3ed708c21a698
Source dataset
uspto-grants-1981_07
Patent number
US04280831

Reaction notes

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