2-Amino-5-(trifluoromethyl)pyridine → HCID 13023075, compound

HRID 1278180Notes

Reaction equation

HRID 1278180 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([F:23])([F:14])[F:24])=[CH:21][N:20]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 13023075HCID 13023075, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 1.1 g. portion of 2,6-dichlorobenzoyl isocyanate and 0.8 g. of 5-trifluoromethyl-2-aminopyridine were mixed in 50 ml. of ethyl acetate at ambient temperature and stirred for 18 hours. The solvent was then evaporated and the product was recrystallized from ethanol to obtain 0.2 g. of the product named above, m.p. 228°-230° C. Elemental analysis showed:

Workup

  1. customThe solvent was then evaporated
  2. customthe product was recrystallized from ethanol
  3. customto obtain 0.2 g

Sources & evidence

ORD record
ord-6572f903377c40a1ab93b4393cd5aeeb
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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