Dimethylformamide dimethyl acetal → HCID 2805911, compound

HRID 1278197Notes

Reaction equation

HRID 1278197 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][C:7]([CH3:10])=[CH:8][CH:9]=1)(=[O:3])[CH3:2].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][C:7]([CH3:10])=[CH:8][CH:9]=1)=[O:3]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 952923-Acetyl-6-methylpyridine

Product 1

HCID 2805911HCID 2805911, compound

Procedure

As for Example 1, 3-acetyl-6-methylpyridine is refluxed with N,N-dimethylformamide dimethylacetal to yield 3-dimethylamino-1-(6-methyl-3-pyridyl)-2-propen-1-one. The preceding compound is heated at reflux temperature for 6 hours with 3-amino-4-chloropyrazole in glacial acetic acid to give the product of the example.

Sources & evidence

ORD record
ord-395ba8ed56574b748840be6a40c0f7d2
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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