2-(Dimethylamino)ethanol → HCID 21163094, compound

HRID 1278235Notes

Reaction equation

HRID 1278235 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[H-].[Na+].[H-].[CH3:24][N:25](C)[CH2:26]CO>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([O:18][CH2:19][CH2:20][N:25]([CH3:26])[CH3:24])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

Participants

5

Reactant 4

HCID 79022-(Dimethylamino)ethanolHCID 24758Sodium hydrideHCID 166653HydrideHCID 11196438ETHYL 7-(PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE

Product 1

HCID 21163094HCID 21163094, compound

Procedure

To a mixture of ethyl 7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate in 2-dimethylamino ethanol is added sodium hydride. After the hydride is reacted the mixture is heated on a steam bath for 6 hours. The solvent is removed and the residue acidified with dilute acetic acid to give the product of the example.

Workup

  1. temperatureis heated on a steam bath for 6 hours
  2. customThe solvent is removed
  3. customto give the product of the example

Sources & evidence

ORD record
ord-c1a664971f7d424facbde7b8cddcf8d7
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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