Glycol monoethyl ether → HCID 21163083, compound

HRID 1278236Notes

Reaction equation

HRID 1278236 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[CH2:21]([O:23]CCO)[CH3:22].[H-].[Na+].[H-]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([O:18][CH2:19][CH2:20][O:23][CH2:21][CH3:22])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

Participants

5

Reactant 4

HCID 8076Glycol monoethyl etherHCID 24758Sodium hydrideHCID 166653HydrideHCID 11196438ETHYL 7-(PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE

Product 1

HCID 21163083HCID 21163083, compound

Procedure

To a mixture of ethyl 7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate and 2-ethoxyethanol is added sodium hydride. After the hydride is reacted, the mixture is heated on a steam bath for 12 hours. The solvent is removed and the residue is acidified with dilute acetic acid to give the product of the example.

Workup

  1. temperaturethe mixture is heated on a steam bath for 12 hours
  2. customThe solvent is removed
  3. customto give the product of the example

Sources & evidence

ORD record
ord-990130447918491cb3a08531fd5ef381
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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