Hydrochloric Acid → HCID 12881339, compound

HRID 1278360Notes

Reaction equation

HRID 1278360 reaction equation
C[O:2][C:3](=[O:18])/[CH:4]=[CH:5]/[N:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:17])[CH:13]=2)[N:8]=[CH:7]1.Cl.C(O)(=O)C=C>O>[OH:17][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6](/[CH:5]=[CH:4]/[C:3]([OH:18])=[O:2])[C:15]2=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6581Acrylic AcidHCID 12881325HCID 12881325, compound

Product 1

HCID 12881339HCID 12881339, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 8.35 g. of trans-3-(6-hydroxy-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid methyl ester and 500 ml. of 6 N hydrochloric acid was stirred and refluxed for 15 minutes. After cooling, water was added and the resultant solid was filtered to yield 6.33 g., m.p. 294°-296°; of trans-3-hydroxy-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid.

Workup

  1. additionA mixture of 8.35 g
  2. temperaturerefluxed for 15 minutes
  3. temperatureAfter cooling
  4. filtrationthe resultant solid was filtered
  5. customto yield 6.33 g

Sources & evidence

ORD record
ord-46c75d95f6da46739355cf68468ab4cb
Source dataset
uspto-grants-1981_07
Patent number
US04281127

Reaction notes

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