Sorbitol → HCID 86586928, compound

HRID 1278522Notes

Reaction equation

HRID 1278522 reaction equation
[C:1](=[O:4])([OH:3])[O-:2].[Na+:5].[OH:6][CH2:7][C@@H:8]([C@H:10]([C@@H:12]([C@@H:14]([CH2:16][OH:17])[OH:15])[OH:13])[OH:11])[OH:9]>O>[C:1](=[O:2])([OH:4])[O-:3].[Na+:5].[OH:17][CH2:16][C@@H:14]([C@H:12]([C@@H:10]([C@@H:8]([CH2:7][OH:6])[OH:9])[OH:11])[OH:13])[OH:15]

Participants

4

Reactant 2

HCID 5780SorbitolHCID 516892Sodium Bicarbonate

Product 1

HCID 86586928HCID 86586928, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

147 g (1.75 moles) of sodium bicarbonate, 540 g of water, and 390 g of a 70% sorbitol solution (i.e. 273 g of 100% sorbitol and 170 g of water) were mixed. 306 g (1.5 moles) of aluminum iso-propoxide, heated to 100° C., then were added to the mixture and stirred for 2 hours. The resulting precipitate was isolated by vacuum filtration. Roughly half the batch filtered rather well. The filtered liquid and unfiltered solid were recombined to prevent loss of sorbitol, air dried, and then oven dried at 100° C. overnight. A 5% (w/w) aqueous suspension of the material then was prepared, and stirred for about 30 minutes with gentle heating in order to ensure complete dispersion. The results are summarized in Table 1, and are as follows: ANC, 0.677; Appearance, translucent; Stability, excellent; Grittiness, none; Evaluation, acceptable.

Workup

  1. additionwere added to the mixture
  2. customThe resulting precipitate was isolated by vacuum filtration
  3. filtrationRoughly half the batch filtered rather well
  4. customdried
  5. customoven dried at 100° C. overnight
  6. additionA 5% (w/w) aqueous suspension of the material
  7. customthen was prepared
  8. stirringstirred for about 30 minutes
  9. temperaturewith gentle heating in order

Sources & evidence

ORD record
ord-fd70576d1fd1480e9591ec2ca8360681
Source dataset
uspto-grants-2002_09
Patent number
US06444232B1

Reaction notes

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