HRID1278549

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O

HCID441298

CHEBI:5834

C35H52O4

HCID5360545

Sodium

PRODUCTS

生成物

结构：CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O.[Na]

HCID70148574

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

23 mg (1 mmol) sodium is dissolved in 50 ml anhydrous methanol. 536 mg (1 mmol) hyperforin is dissolved in this solution under stirring, and the solution evaporated. The residue is dissolved in 100 ml water and lyophilised. Yield: 556 mg of a light-coloured powder (99.6% of theoretical). Mp.: Degradation from 170° C. IR: 1420-1500 cm−(sv).

WORKUP

后处理

customthe solution evaporated
dissolutionThe residue is dissolved in 100 ml water
customfrom 170° C

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de10881907ed4ef0a57acda5aa179634
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06444662B1
来源说明: uspto-grants-2002_09

反应 SMILES

[Na:1].[CH3:2][CH:3]([C:5]([C@@:7]12[C@@:17]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23])([CH3:18])[C@@H:16]([CH2:25][CH:26]=[C:27]([CH3:29])[CH3:28])[CH2:15][C@@:12]([CH2:30][CH:31]=[C:32]([CH3:34])[CH3:33])([C:13]1=[O:14])[C:11]([OH:35])=[C:10]([CH2:36][CH:37]=[C:38]([CH3:40])[CH3:39])[C:8]2=[O:9])=[O:6])[CH3:4]>CO>[CH3:4][CH:3]([C:5]([C@@:7]12[C@@:17]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:23])[CH3:24])([CH3:18])[C@@H:16]([CH2:25][CH:26]=[C:27]([CH3:28])[CH3:29])[CH2:15][C@@:12]([CH2:30][CH:31]=[C:32]([CH3:34])[CH3:33])([C:13]1=[O:14])[C:11]([OH:35])=[C:10]([CH2:36][CH:37]=[C:38]([CH3:40])[CH3:39])[C:8]2=[O:9])=[O:6])[CH3:2].[Na:1]