HCID 18430853, compound → HCID 18430868, compound

HRID 1278622Notes

Reaction equation

HRID 1278622 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2([CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[OH-].[Pd+2].[OH-]>[N:11]1([CH2:14][CH2:15][C:16]2([CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH2:17][CH2:18][CH2:19][CH2:20]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 18430853HCID 18430853, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18430868HCID 18430868, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-[[1-[2-(4-benzyl-1-piperazinyl)ethyl]cyclopentyl]methyl]-2-pyrrolidinone (408 mg) and palladium hydroxide (41 mg) in methanol (5.5 ml) was stirred under hydrogen (4 kg) for 7 hours. After hydrogen was replaced with nitrogen, the mixture was filtered through Celite. The filtrate was concentrated in vacuo to provide a yellow oil. (345 mg/100%)

Workup

  1. filtrationthe mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated in vacuo
  3. customto provide a yellow oil

Sources & evidence

ORD record
ord-c5747c3f7a514c8c8bae52d29e355774
Source dataset
uspto-grants-2002_09
Patent number
US06444677B2

Reaction notes

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