Acetic Acid → HCID 18431531, compound

HRID 1278910Notes

Reaction equation

HRID 1278910 reaction equation
[H-].[Na+].[C:3]([CH2:8][C:9]([NH:11][CH3:12])=[O:10])([O:5][CH2:6][CH3:7])=[O:4].[C:13](O)(=O)C>C(O)(C)C>[C:3]([CH2:8][C:9]([NH:11][CH3:12])=[O:10])([O:5][CH:6]([CH3:13])[CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24758Sodium hydrideHCID 11321015Ethyl-N-methyl malonamide

Product 1

HCID 18431531HCID 18431531, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1.4 g sodium hydride (60% in mineral oil) are added to a solution prepared by dissolving 101.5 g of 2-carboethoxy-N-methyl-acetamide in 11 of isopropanol. The reaction is maintained at room temperature for 5 hours. The mixture is neutralised with acetic acid, then the solvent is removed at reduced pressure, and the product is isolated by distillation at 6 mmHg (Teb 115° C.). 91.4 g of 2-carboisopropoxy-N-methyl-acetamide are obtained (yield 82%).

Workup

  1. customprepared
  2. customthe solvent is removed at reduced pressure
  3. customthe product is isolated by distillation at 6 mmHg (Teb 115° C.)

Sources & evidence

ORD record
ord-cbb8f798e5034c5f8d9f023d2304b418
Source dataset
uspto-grants-2002_09
Patent number
US06444822B1

Reaction notes

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