反应详情

Triethyl 2-phosphonopropionate (0.714 mol, 153 ml) was dissolved in THF (75 ml) and added slowly to NaH (1.0 mol, 24.3 g) in THF (60 ml) at 0° C. The mixture was slowly warmed to room temperature and stirring was continued for 1 h after gas evolution had ceased. The temperature was lowered to −10° C. and a solution of the above described 1-Phenylpyrrole-2-carbaldehyde (0.665 mol, 113.0 g) in 200 ml of THF was added dropwise. The flask and contents were warmed to room temperature over a 30 minute period resulting in a thick precipitate which decoupled the magnetic stirrer. A saturated solution of NH4Cl (100 ml) was added cautiously dissolving the precipitate to give a two phase solution. After evaporating the THF, the crude product was extracted with ether (2×200 ml). The extract was washed with brine solution, dried over MgSO4, and solvents were removed on a rotoevaporator. Yield: 178 g of product as a white solid (98%). The title compound was analysed by 1H-NMR and 13C-NMR spectroscopy.

1. customwas lowered to −10° C.
2. additionwas added dropwise
3. temperatureThe flask and contents were warmed to room temperature over a 30 minute period
4. customresulting in a thick precipitate which
5. dissolutiondissolving the precipitate
6. customto give a two phase solution
7. customAfter evaporating the THF
8. extractionthe crude product was extracted with ether (2×200 ml)
9. washThe extract was washed with brine solution
10. dry with materialdried over MgSO4, and solvents
11. customwere removed on a rotoevaporator