Hydrogen Bromide → 4-Methylisoquinolin-7-ol

HRID 127918Notes

Reaction equation

HRID 127918 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:13])=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1.Br>>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:13])=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 205232037-Methoxy-4-methylisoquinoline

Product 1

HCID 205232214-Methylisoquinolin-7-ol

Procedure

A mixture of 17.3 g. (0.1 mole) of 7-methoxy-4-methylisoquinoline and 100 ml. of 48% hydrobromic acid is refluxed for sixteen hours and evaporated in vacuo. The residue is dissolved in water, neutralized with ammonium hydroxide and filtered to yield 7-hydroxy-4-methylisoquinoline.

Workup

  1. additionA mixture of 17.3 g
  2. customevaporated in vacuo
  3. dissolutionThe residue is dissolved in water
  4. filtrationfiltered

Sources & evidence

ORD record
ord-948ffba10f3c482688859b302143d3f1
Source dataset
uspto-grants-1981_03
Patent number
US04258049

Reaction notes

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