Hydrochloric Acid → HCID 10083993, compound

Temperature

60 °C

1.00 (6.80 mmole) of dichlorobenzene and 0.72 g (7.14 mmole) of succinic anhydride were suspended in 3 ml of dichloroethane and 1.36 g (10.2 mmole) of aluminum chloride powder were added. The mixture was then stirred at 60° C. for 3 hours. At the end of this time, the reaction mixture was ice-cooled and 1 N aqueous hydrochloric acid was added. The mixture was then extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was dissolved in 30 ml of methanol, and 0.20 ml of an aqueous solution of sulfuric acid was added. The solution was then heated under reflux for 2 hours, after which the reaction mixture was cooled to room temperature, poured into water and then extracted with diethyl ether. The organic extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and diethyl ether ranging from 17:3 to 7:3 by volume as the eluent, to obtain 0.25 g (yield 14%) of the title compound as pale orange crystals.

1. temperaturecooled
2. extractionThe mixture was then extracted with methylene chloride
3. extractionThe organic extract
4. washwas washed with a saturated aqueous solution of sodium chloride
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was then removed by distillation under reduced pressure
7. dissolutionThe resulting residue was dissolved in 30 ml of methanol
8. addition0.20 ml of an aqueous solution of sulfuric acid was added
9. temperatureThe solution was then heated
10. temperatureunder reflux for 2 hours
11. temperatureafter which the reaction mixture was cooled to room temperature
12. additionpoured into water
13. extractionextracted with diethyl ether
14. extractionThe organic extract
15. washwas washed with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order
16. dry with materialdried over anhydrous sodium sulfate
17. customThe solvent was then removed by distillation under reduced pressure
18. customThe resulting residue was purified by silica gel column chromatography
19. washa gradient elution method

ORD record

ord-53e4ab77a64147bfb405ca68f1ee56d4

Source dataset

uspto-grants-2002_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06448247B1