Hydrochloric Acid → HCID 18770438, compound

HRID 1279427Notes

Reaction equation

HRID 1279427 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([CH2:21][CH:22]2[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]2)[C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[NH:9]1[CH2:10][CH2:11][CH:12]([CH2:15][CH:16]([CH2:21][CH:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[C:17]([O:19][CH3:20])=[O:18])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770408HCID 18770408, compound

Product 1

HCID 18770438HCID 18770438, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 4N hydrogen chloride in ethyl acetate (1.0 ml; 4.0 mmol) was added to a solution in ethyl acetate (0.5 ml) of methyl 2,2-bis[(1-tert-butoxycarbonyl-4-piperidinyl)-methyl]acetate (210 mg; 0.45 mmol) synthesized by the above process, and the mixture was stirred at room temperature for 30 minutes and then concentrated under reduced pressure. The concentrated residue was suspended in diethyl ether and collected by filtration to obtain 116 mg (yield: 76%) of the title compound as a colorless crystalline powder (melting point: 269-271° C.).

Workup

  1. customsynthesized by the above process
  2. concentrationconcentrated under reduced pressure
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-52983abde4f543388ecdd75bbaff16e4
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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