Hydrochloric Acid → HCID 18770379, compound

HRID 1279443Notes

Reaction equation

HRID 1279443 reaction equation
[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=[CH:15]/[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][N:27]3[CH2:32][CH2:31][N:30]([C:33](=[O:50])/[CH:34]=[CH:35]/[CH:36]=[CH:37]/[C:38]4[CH:43]=[CH:42][C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])=[CH:40][C:39]=4[O:48][CH3:49])[CH2:29][CH2:28]3)[CH2:20][CH2:19]2)=[O:17])=[C:8]([O:51][CH3:52])[CH:7]=1)([CH3:5])([CH3:4])[CH3:3]>C(O)C>[ClH:1].[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=[CH:15]/[C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][N:27]3[CH2:32][CH2:31][N:30]([C:33](=[O:50])/[CH:34]=[CH:35]/[CH:36]=[CH:37]/[C:38]4[CH:43]=[CH:42][C:41]([C:44]([CH3:45])([CH3:47])[CH3:46])=[CH:40][C:39]=4[O:48][CH3:49])[CH2:29][CH2:28]3)[CH2:22][CH2:23]2)=[O:17])=[C:8]([O:51][CH3:52])[CH:7]=1)([CH3:3])([CH3:4])[CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12988315HCID 12988315, compound

Product 1

HCID 18770379HCID 18770379, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.025 ml; 0.30 mmol) was added to a solution of 1,3-bis[4-[(E,E)-5-(4-tert-butyl-2-methoxyphenyl)-2,4-pentadienoyl]-1-piperazinyl]-propane (49 mg; 0.070 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-78f327ea07b149c888fdad109fa1cd85
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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