Hydrochloric Acid → HCID 18770416, compound
Reaction equation
[ClH:1].[F:2][C:3]([F:48])([F:47])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[CH:12]=[CH:13]/[C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][N:25]3[CH2:30][CH2:29][N:28]([C:31](=[O:46])/[CH:32]=[CH:33]/[CH:34]=[CH:35]/[C:36]4[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:44])[F:43])=[CH:38][CH:37]=4)[CH2:27][CH2:26]3)[CH2:18][CH2:17]2)=[O:15])=[CH:6][CH:5]=1>C(O)C>[ClH:1].[ClH:1].[F:44][C:42]([F:43])([F:45])[C:39]1[CH:40]=[CH:41][C:36](/[CH:35]=[CH:34]/[CH:33]=[CH:32]/[C:31]([N:28]2[CH2:29][CH2:30][N:25]([CH2:24][CH2:23][CH2:22][N:19]3[CH2:20][CH2:21][N:16]([C:14](=[O:15])/[CH:13]=[CH:12]/[CH:11]=[CH:10]/[C:7]4[CH:6]=[CH:5][C:4]([C:3]([F:47])([F:48])[F:2])=[CH:9][CH:8]=4)[CH2:17][CH2:18]3)[CH2:26][CH2:27]2)=[O:46])=[CH:37][CH:38]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.040 ml; 0.48 mmol) was added to a solution of 1,3-bis[4-[(E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoyl]-1-piperazinyl]propane (111 mg; 0.16 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from ethanol-diethyl ether to obtain the title compound as a colorless crystalline powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- customthe resultant concentrated residue was recrystallized from ethanol-diethyl ether
Sources & evidence
- ORD record
- ord-b7ec4ba554ce440e8775ad712ea6d812
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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