Hydrochloric Acid → HCID 18770399, compound

HRID 1279457Notes

Reaction equation

HRID 1279457 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:61]=[CH:60][C:17]([C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][N:34]5[CH2:39][CH2:38][N:37]([C:40](=[O:59])[C:41]6[CH:46]=[CH:45][C:44]([C:47]7[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=7)=[CH:43][CH:42]=6)[CH2:36][CH2:35]5)[N:28]=4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][CH:15]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([N:20]3[CH2:21][CH2:22][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][N:34]5[CH2:39][CH2:38][N:37]([C:40](=[O:59])[C:41]6[CH:46]=[CH:45][C:44]([C:47]7[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=7)=[CH:43][CH:42]=6)[CH2:36][CH2:35]5)[N:28]=4)[CH2:24][CH2:25]3)=[O:19])=[CH:60][CH:61]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770400HCID 18770400, compound

Product 1

HCID 18770399HCID 18770399, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.080 ml; 0.96 mmol) was added to a solution of 2,6-bis[[4-[4-(3,4,5-trimethoxyphenyl)benzoyl]-1-piperazinyl]methyl]pyridine (157 mg; 0.19 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as a colorless crystalline powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
  3. customthe resultant concentrated residue was recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-f3adfa3cb0a94f7b855e0b24954e4a05
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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