2-Amino-6-chlorobenzoic acid → Methyl 2-amino-6-chlorobenzoate

HRID 1279490Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][Si](C=[N+]=[N-])(C)C>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:3]=1[C:4]([O:6][CH3:12])=[O:5]

Participants

Reactant 2

HCID 750712-Amino-6-chlorobenzoic acid

HCID 167693Trimethylsilyldiazomethane

Product 1

HCID 592849Methyl 2-amino-6-chlorobenzoate

Procedure

2-Amino-6-chlorobenzoic acid is reacted with trimethylsilyldiazomethane to yield methyl 2-amino-6-chlorobenzoate (Chem. Pharm. Bull. Vol. 29, 1475 (1981)).

Sources & evidence

ORD record: ord-132c7a0bda8b4fb4b87934e86665b954
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06448277B2

Reaction notes

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