p-Toluenesulfonic acid → 4-Methyl-5-(2-propenyl)pyrrolidin-2-one

HRID 1279560Notes

Reaction equation

HRID 1279560 reaction equation
O[CH2:2][CH2:3][CH2:4][CH:5]1[NH:9][C:8](=[O:10])[CH2:7][CH:6]1[CH3:11].CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:11][CH:6]1[CH:5]([CH2:4][CH:3]=[CH2:2])[NH:9][C:8](=[O:10])[CH2:7]1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 184285635-(3-Hydroxypropyl)-4-methylpyrrolidin-2-one

Product 1

HCID 187821034-Methyl-5-(2-propenyl)pyrrolidin-2-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The product of EXAMPLE 235 is treated with PTSA in refluxing toluene, with a Dean-Stark trap to remove water. The solvent is removed to yield the title material.

Workup

  1. customwith a Dean-Stark trap to remove water
  2. customThe solvent is removed

Sources & evidence

ORD record
ord-cf10568937ee4306b9b4bd20cf50ee67
Source dataset
uspto-grants-2002_09
Patent number
US06448286B1

Reaction notes

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