Methyl iodide → HCID 12017704, compound

HRID 1279611Notes

Reaction equation

[CH:1]([N:4]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(=[O:29])=[O:28])[C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:6]=1[NH:15][CH2:16][C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][CH:18]=1)([CH3:3])[CH3:2].[C:36]1(S(NC2C=CC(C(F)(F)F)=CC=2NCC2C=CC(C(OC)=O)=CC=2)(=O)=O)C=CC=CC=1.[H-].[Na+].CI>CN(C=O)C>[CH3:36][N:15]([CH2:16][C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][CH:18]=1)[C:6]1[CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=[CH:10][C:5]=1[N:4]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(=[O:29])=[O:28])[CH:1]([CH3:3])[CH3:2]

Participants

Conditions

Temperature: 60 °C

Procedure

Methyl 4-[2-(N-Isopropyl-phenylsulfonylamino)-5-trifluoromethylphenylaminomethyl]benzoate (200 mg) prepared by the same procedure as Example 17 by using methyl 4-(2-phenylsulfonylamino-5-trifluoromethylphenylaminomethyl)benzoate (prepared in Example 27.) was dissolved in DMF (5 ml). Sodium hydride (64 mg) and methyl iodide (200 μl) were added thereto. The mixture was stirred for 24 hours at 60° C. The reaction mixture was extracted with H2O-AcOEt, washed, dried over, filtered and concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (hexane:AcOEt=5:1) to give the title compound (105 mg) having the following physical data.

Workup

extractionThe reaction mixture was extracted with H2O-AcOEt
washwashed
customdried over,
filtrationfiltered
concentrationconcentrated under the reduced pressure
customThe residue was purified on silica gel column chromatography (hexane:AcOEt=5:1)

Sources & evidence

ORD record: ord-6112bb6ee0894c479cf9c48bf58db621
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06448290B1

Reaction notes

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