4-Chlorobenzenesulfonyl chloride → HCID 23470966, compound

HRID 127979Notes

Reaction equation

HRID 127979 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:18]=[CH:17][C:7]([O:8][CH:9]([CH2:13][CH2:14][CH2:15][CH3:16])[C:10]([OH:12])=[O:11])=[CH:6][CH:5]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([NH:1][CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:13][CH2:14][CH2:15][CH3:16])[C:10]([OH:12])=[O:11])=[CH:17][CH:18]=2)(=[O:28])=[O:27])=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 11430Potassium CarbonateHCID 23470963HCID 23470963, compound

Product 1

HCID 23470966HCID 23470966, compoundYield 32%

Procedure

By the reaction of 2-[4-(2-aminoethyl)-phenoxy]-n-hexanoic acid with 4-chlorobenzenesulphonyl chloride in the presence of aqueous potassium carbonate solution, in a manner analogous to that described in Example 1, there is obtained a yield of 32% of theory of 2-{4-[2-(4-chlorobenzenesulphonylamino)-ethyl]-phenoxy}-n-hexanoic acid; m.p. 138°-139° C. (recrystallized from ethyl acetate and cyclohexane).

Sources & evidence

ORD record
ord-29b41d65b70e41adb45c55c1abc9964f
Source dataset
uspto-grants-1981_03
Patent number
US04258058

Reaction notes

Loading…